Electronmicroscopy studies on the opsonic role of antiserum and the subsequent destruction of salmonellae within murine inflammatory leukocytes343

Summary Inbred female C3H mice were given, by intraperitoneal injection, 4 × 107 virulent Salmonella typhimurium organisms opsonised with specific antiserum. Peritoneal washings were obtained between 1.5 and 24 h after injection and examined by electronmicroscopy. Opsonised salmonellae were ingested rapidly by peritoneal exu-date cells and were digested rapidly. The presence of antibody facilitated the phagocytic efficiency of the host cells. Destruction of ingested bacteria appeared to be an innate capacity of the host phagocytes independent of the presence of antibody.