Thiazolobenzyne: a versatile intermediate for multisubstituted benzothiazoles
2016
Thiazolobenzyne, which is a benzyne species fused with a thiazole ring, was efficiently generated via an iodine–magnesium exchange reaction of an ortho-iodoaryl triflate-type precursor using a trimethylsilylmethyl Grignard reagent as an activator. A wide range of arynophiles reacted efficiently with the thiazolobenzynes generated by this method to afford various multisubstituted benzothiazoles.
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