S-1–Induced Lacrimal Drainage Obstruction and Its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-institutional Study

Namju Kim,Jin Won Kim,Je-Hyun Baek,Jin Soo Kim,Ho-Kyung Choung,Tae Yong Kim,Kyung-Hun Lee,Yung-Jue Bang,Sang In Khwarg,Sang-Hoon Ahn,Do Joong Park,Hyung-Ho Kim,Jae-Yong Chung,Soyeon Ahn,Keun-Wook Lee

S-1–Induced Lacrimal Drainage Obstruction and Its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-institutional Study

2017

Namju Kim
Jin Won Kim
Je-Hyun Baek
Jin Soo Kim
Ho-Kyung Choung
Tae Yong Kim
Kyung-Hun Lee
Yung-Jue Bang
Sang In Khwarg
Sang-Hoon Ahn
Do Joong Park
Hyung-Ho Kim
Jae-Yong Chung
Soyeon Ahn
Keun-Wook Lee

Purpose This prospective study was conducted to determine the incidence of lacrimal drainage obstruction (LDO) during S-1 chemotherapy and evaluate the association between the development of LDO and the concentrations of ingredients/metabolites of S-1 in tears and plasma.

Keywords:

General surgery
Fluorouracil
Lacrimal drainage
Tears
Medicine
Surgery
Trough level
Renal function
Adverse effect
Nasolacrimal duct
Tegafur
Prospective cohort study
Hazard ratio

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