THE PHARMACOLOGY OF INFLAMMATION II. TUE INHIBITING EFFECT OF SOME BENZOATES

1. The ammonium salts of benzoic, ortho-iodo benzoic, orthoiodoso benzoic, para-iodoso benzoic, and ortho-iodoxy benzoic acids, given intravenously or intraperitoneally, inhibit the edema of the conjunctival sac of rabbits produced by 15 per cent mustard oil. 2. The inhibiting action of the ortho-iodoxy benzoate is not due to a fall in blood pressure. 3. A table is appended which shows the relationship between the minimal effective antiedemic dose and the minimal lethal dose to be essentially a constant (from 50 to 66 per cent). The doses of the individual drugs vary from 75 to 325 mgm. per kilogram. 4. The contention of various authors (26, 29, 41, 43 and 45) that local anesthesia by drugs does not inhibit mustard oil edema was confirmed.