Effects of extracted compound rhodiola on SOD activity and MDA content in serum of the rat after +Gz exposure

Objective To observe the effects of extracted compound rhodiola on superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the serum of rat after + Gz exposure.Methods Seventy-two male SD rats were averagely divided into six groups:normal control group,binding group,+10 Gz group and compound rhodiola extract low,middle,and high dosage groups with extracted compound rhodiola.The low,middle,and high dosage group was respectwely administrated with the dosages of 0.75 g/kg,1.5 g/kg and 3.0 g/kg and the others were given distilled water.Except normal control group and binding group,the other groups were exposed to+10 Gz after daily intragastric administration for 14 days.The serum of rats was collected,and its SOD activity and MDA content were determined subsequently.Results The weight of rats increased significantly and there was no statistical difference among all the groups.Compared with normal control group,SOD activity of high dosage group was slightly changed but the other group's was decreased significantly (P＜0.01).Compared with binding group and+ 10 Gz group,SOD activity of middle and high dosage group was increased obviously (P＜0.01).MDA content of middle dosage group was significantly decreased after +10 Gz exposure.Conclusions Compound rhodiola can increase SOD activity and decrease MDA content of rat serum after+Gz exposure.The results indicate that compound rhodiola would be effective in protecting +Gz induced organism damage. Key words: Rhodiola sacra; Hypergravity; Acceleration; Superoxide dismutase; Malondialdehyde; Rats