Effect of Ampicillin, Streptomycin, Penicillin and Tetracyclineon Metal Resistant and Non-Resistant Staphylococcus aureus
2014
There is an arising and concerning issue in the field of
bacterial resistance, which is confirmed by the number of
deaths associated with drug-resistant bacterial infections. The
aim of this study was to compare the effects of antibiotics on
Staphylococcus aureus non-resistant strain and strains
resistant to cadmium or lead ions. Metal resistant strains were
created by the gradual addition of 2 mM solution of metal ions
(cadmium or lead) to the S. aureus culture. An increasing
antimicrobial effect of ampicillin, streptomycin, penicillin
and tetracycline (0, 10, 25, 50, 75, 150, 225 and 300 mu M) on
the resistant strains was observed using a method of growth
curves. A significant growth inhibition (compared to control)
of cadmium resistant cells was observed in the presence of all
the four different antibiotics. On the other hand, the addition
of streptomycin and ampicillin did not inhibit the growth of
lead resistant strain. Other antibiotics were still toxic to
the bacterial cells. Significant differences in the morphology
of cell walls were indicated by changes in the cell shape. Our
data show that the presence of metal ions in the urban
environment may contribute to the development of bacterial
strain resistance to other substances including antibiotics,
which would have an impact on public health.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI