ЗАЩИТНОЕ ДЕЙСТВИЕ ПЕПТИДА ПРОЛИЛ-ГЛИЦИЛ-ПРОЛИНА (PGP) ПРИ АНАФИЛАКТОИДНОЙ РЕАКЦИИ У МЫШЕЙ, ВЫЗВАННОЙ ВЕЩЕСТВОМ 48/80

The   influences  of  PGP  on   compound  48/80-induced  anaphylactoid  reaction  development in  mice   and   on   histamine  secretion  from   rat   peritoneal  mast   cells  (RPMC)  were  investigated. Anaphylactoid reaction  was  induced  by  intraperitoneal  injection  of  compound  48/80   into   mice. The  amount of histamine secreted by RPMC was evaluated. Injection of  PGP 15  min  before  injection of  compound 48/80   led  to  decrease of  mortality, and  some  of anaphylactoid reaction symptoms reduced. PGP had  no  effect  on  compound 48/80-induced  histamine secretion from  (RPMC) in  vitro.