A practical preparation of highly versatile N-acylpyrroles from 2,4,4-trimethoxybutan-1-amine.
2012
A novel method for the preparation of N-acylpyrrole is described. The method involves condensation of carboxylic acids with 2,4,4-trimethoxybutan-1-amine, followed by acid-mediated cyclization to form the pyrrole ring. The preparative procedure is highly tolerant of a variety of functional groups.
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