Optimization of trabectedin temporal protocol using mathematical PK/PD modeling.

Maeva Andriantsoa,Raouf El Cheikh,Diane-Charlotte Imbs,Raphaël Serre,Florence Duffaud,Joseph Ciccolini,Dominique Barbolosi,Sébastien Salas

Optimization of trabectedin temporal protocol using mathematical PK/PD modeling.

2018

Maeva Andriantsoa
Raouf El Cheikh
Diane-Charlotte Imbs
Raphaël Serre
Florence Duffaud
Joseph Ciccolini
Dominique Barbolosi
Sébastien Salas

e23553Background: Trabectedin (ET-743, Yondelis) is an antineoplastic agent indicated for the treatment of advanced soft tissue sarcomas (STS). Despite its efficacy, Trabectedin induces severe toxi...

Keywords:

PK/PD models
Physical therapy
Trabectedin
Cancer research
Medicine
Oncology
Soft tissue
Internal medicine
Pathology

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