Fluoreszenzbildgebung in der Laryngologie@@@Fluorescence imaging in laryngology: Physikalische Grundlagen, klinische Anwendung und Studienergebnisse@@@Physical principles, clinical applications and study results

Early detection and adequate preoperative assessment of neoplastic lesions of the larynx allow for voice-preserving therapy concepts. The physical principles, clinical applications and most important study results of fluorescence imaging are presented. The entire literature on autofluorescence endoscopy of the larynx was analysed and compared to induced fluorescence endoscopy. In detecting malignant and premalignant lesions of the larynx, autofluorescence endoscopy shows a significantly higher sensitivity, specificity and accuracy than white light endoscopy alone. Induced fluorescence endoscopy achieved an even higher sensitivity, albeit at the expense of specificity. Autofluorescence endoscopy represents a simple screening procedure for early detection of laryngeal cancer and its precursor lesions, whereas induced fluorescence endoscopy is more suited for the identification of recurrent disease.