Vital relationship between osteopontin and urolothiasis

Abstract Urological rediscovery of osteopontin (OPN) in 1992 has opened a new era in the understanding of mechanisms in development of urolithiasis over the two decades. OPN had the multiple functions, and it was difficult to understand the overall role. It has been understood that OPN is a promoting agent for urolithiasis development in the issue as a result of a lot of experiments. And it became clear that OPN having received the control of free radicals from NADPH oxidase and angiotensin II . The clinical application that uses OPN antibody and/or ARB for preventing urolithiasis is expected. I describe the vital role of OPN in development of urolithiasis in this paragraph.