Caso clínico Primer caso de hemoglobina Köln (codon98 GTG>ATG) en Costa Rica (First case of hemoglobin Köln (codon98 GTG>ATG) in Costa Rica)

Exposure to certain drugs may result in hemolytic anemia with the appearance of Heinz-bodies in red blood cells. This type of hemolytic anemia may occur by simple drug overdosage in absence of any known abnormality, such as in normal persons or in patients with erithroid enzyme defects (e.g. G6PD deficiency) or unstable hemoglobins. 1 The present report shows a Heinz-body hemolytic anemia because of an abnormal hemoglobin. High pressure liquid chromatography (HPLC) and molecular analysis confirmed the first case of Hemoglobin Koln in Costa Rica.