Fabrication of biodegradable auto-fluorescent organosilica nanoparticles with dendritic mesoporous structures for pH/redox-responsive drug release

Abstract In this work, disulfide-bridged organic silica (OS) based nanocarriers were constructed for drug release. The broken of S S bonds in Si-O-Si skeleton would improve the degradation of Si-O-Si of OS carriers. The OS carriers have a central-radiated dendritic porous structure and a large specific surface area of 453.80 m2g−1. The dextrin was selectively oxidized to dialdehyde dextrin (DAD) and then was modified on the surface of OS carriers by Schiff base bonds. Subsequently, cystamine (Cys) was linked with DAD to form DAD/Cys layer (OS-N=C-DAD/Cys) to seal the loaded drug. The DAD/Cys layer display the degradation performance of pH/GSH dual response The obtained OS-N=C-DAD/Cys carriers displayed low premature and the cumulative release was 6.5% under normal physiological conditions within 48 h. The Schiff base (-N=C-) structure in the DAD/Cys layer is also capable of monitoring acid-responsive drug release by fluorescence change. The prepared OS-N=C-DAD/Cys carriers and their degraded products have high biocompatibility.