Photocarcinogenesis and Consumer Product Testing: Technical Aspects
1991
AbstractSummary: Photocarcinogenesis is the production of tumors by sunlight. Since consumer products have been found to modify the course of cutaneous photocarcinogenesis in animal models, and since this modification is thought to be clinically relevant, we have developed and implemented procedures to evaluate a test article/substance as a potential modifier of photocarcinogenesis. Prior to beginning a photocarcinogenesis study, range-finding studies are conducted to determine certain characteristics of the test article/substance and its vehicle (e.g., primary irritancy, photosensitivity, and photoprotection). Additionally, the doses of test article/substance, the doses of sunlight exposure, and the most appropriate sequence for administering these two variables are determined from the range-finding studies and the intended use of the test article/substance. The test system is the Crl:SKH1 (hr/hr)BR, albino, hairless mouse. The source of “sunlight” is a 6.5 kW xenon arc lamp modified to emit radiation th...
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