Antimicrobial Drug Resistance and Resistance Factor Transfer among Clinical Isolates of Salmonellae in Iran

508 salmonella strains isolated during 1983–1986 in Tehran, Iran from cases of diarrhoea in children <5 were tested for sensitivity to 10 antimicrobial drugs and their ability to transfer the resistance determinants. Salmonella typhimurium and S. havana were most common (45.7% and 30.9%, respectively) followed by S. typhi (2.9%) and S. larochelle (2.4%). The antimicrobial agents used were chloramphenicol (C), gentamicin (G), tetracycline (T), ampicillin (A), cephalothin (Cf), trimethoprim-sulfamethoxazole (SXT), kanamycin (K), nalidixic acid (Na), streptomycin (S), and furoxone (F). 91 % of the salmonellae isolates contained resistance determinants, of which 89.6% were resistant to more than one agent. Strains resistant to 4–7 drugs comprised 85.6% of the total isolates. Ampicillin resistance was found in 85.4% and nalidixic acid in 2.7%. 58 different patterns of resistance to the antimicrobial agents used were observed, of which C/T/A/SXT/K/S and C/T/A/SXT/K/S/Cf were the most frequently encountered. 71....