The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88
2011
Parasites use multifarious means to manipulate and avoid sterilizing immunity. Melendez and colleagues show that a nematode product triggers macrophage autophagocytosis to degrade the adaptor MyD88 and suppress inflammatory responses.
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