Function of protein phosphatase-1, Glc7, in Saccharomyces cerevisiae.

Abstract Budding yeast, Saccharomyces cerevisiae , and its close relatives are unique among eukaryotes in having a single gene, GLC7 , encoding protein phosphatase-1 (PP1). This enzyme with a highly conserved amino acid sequence controls many processes in all eukaryotic cells. Therefore, the study of Glc7 function offers a unique opportunity to gain a comprehensive understanding of this critical regulatory enzyme. This review summarizes our current knowledge of how Glc7 function modulates processes in the cytoplasm and nucleus. Additionally, global Glc7 regulation is described.