Protective effects of oil of Sardinella pilchardis against subacute chlorpyrifos-induced oxidative stress in female rats

ABSTRACTThis study was conducted to evaluate the protective effects of Sardinella pilchardis oil and vitamin E against chlorpyrifos- (CPF-) induced liver, kidney, and brain oxidative damage in female rats. The rats were divided into 6 experimental groups: the control group, the group treated with fish oil, the group that received fish oil for 2 weeks and CPF orally for 7 days, the group treated only with CPF, the group treated with vitamin E for 2 weeks and CPF for 7 days, and the group treated with vitamin E. Oral exposure to CPF induced a significant increase in serum biochemical parameters; hepatic, kidney, and brain LPO; and a decrease in superoxide dismutase, catalase, and glutathione peroxidase activities. Fish oil or vitamin E decreased significantly the mentioned biochemical parameters as compared to rats treated with CPF alone. This study suggests that fish oil has an ameliorative effect for the alleviation of the oxidative damage induced by CPF.