Sensibilidade e Especificidade dos Métodos da Medicina Nuclear na Identificação e Diferenciação de Gliomas

Introduction: Gliomas are brain tumors of high mortality in adults and high prevalence in children. The good prognosis depends on previous diagnosis, precise staging, complete resection and post-treatment recurrence correction correction. PET scans are promising tools for this purpose and this work aims to address their efficacy. Method: The Pubmed and Virtual Health Library were used as the database to select articles that best attend to the topic: nuclear markers for assessment of glioma. Results: MET-C¹¹ presented sensitivity and specificity of 70-80%. The use of FET-F18 for glioma has a sensitivity of 95% and a specificity of 91%. FDOPA-F18 has a sensitivity of 81% and specificity of 84%. FGD-F18 has accuracy, sensitivity and specificity for generally very limited gliomas, which are 80, 70 and 97% respectively. 68Ga-PRGD2 shows superior efficacy to FGD and maximum capacity in differentiating tumor grade. Conclusion: The best method for the identification of glioma is PET-FET and the most accurate in the differentiation of tumor grade or RGD-PET. The others cited have diagnostic value superior to Magnetic Resonance (MRi) for glioma.