PREPARATIVE OXIDATIVE CONVERSION OF PROTECTED PEPTIDE Cα-HYDRAZIDES INTO THE CORRESPONDING ACIDS BY N-BROMOSUCCINIMIDE

A procedure for the preparative, oxidative conversion of protected peptide hydrazides into the corresponding acids by N-bromosuccinimide is described. Purification was achieved by high performance liquid chromatography on silica gel in chloroform-alcohol-acetic acid systems. Average recovery of purified protected peptide acids was over 90%.