On the Heterogeneity of Linkage Estimations between LA and FOUR Loci of the HL–A System

Three cases of crossing over between the LA and FOUR loci of HL–A system are presented in this note. Recombination fractions between those two loci are also calculated from familial data kindly provided by other European laboratories. It is suggested that differences found in maternal and paternal recombination frequency are due to the heterogeneity of estimates of each laboratory.