Histone Deacetylase Inhibitor Depsipeptide (FK228) Induces Apoptosis in Leukemic Cells by Facilitating Mitochondrial Translocation of Bax, Which Is Enhanced by the Proteasome Inhibitor Bortezomib

Krittaya Sutheesophon,Yukiko Kobayashi,Masaaki Takatoku,Keiya Ozawa,Yasuhiko Kano,Hideshi Ishii,Yusuke Furukawa

Histone Deacetylase Inhibitor Depsipeptide (FK228) Induces Apoptosis in Leukemic Cells by Facilitating Mitochondrial Translocation of Bax, Which Is Enhanced by the Proteasome Inhibitor Bortezomib

2006

Krittaya Sutheesophon
Yukiko Kobayashi
Masaaki Takatoku
Keiya Ozawa
Yasuhiko Kano
Hideshi Ishii
Yusuke Furukawa

Histone deacetylase (HDAC) inhibitors are promising candidates for molecular-targeted therapy for leukemia. In this study, we investigated the mechanisms of cytotoxic effects of depsipeptide (FK228),

Keywords:

Medicine
HDAC10
Histone deacetylase inhibitor
Histone deacetylase 5
HDAC11
Cancer research
Histone deacetylase 2
Histone deacetylase
Depsipeptide
Proteasome inhibitor

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