Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide.

Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory and analgesic, antitumor, antimicrobial, anticonvulsant, among others. The most well known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide, because this compound initially presented important sedative effects. This review approaches some of the recent and efficient chemical synthesis pathway to obtain phthalimide analogues. It is also presented a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.