Changes in total-,HDL-cholesterol, N-acetyl-|[beta]|-glucosaminidase in relation to the quality of metabolic control judged by HbA1 in diabetic children: 11

28 diabetic children were studied. In the fasting blood samples the following substances were measured: glucose, total-cholesterol, HDL-cholesterol, trigly-ceride, N-acetyl-β-glucosaminidase and HbA1.The results obtained were the following: 1.Both fasting blood glucose and urinary glucose excretion were found to be positively related to HbA1 /r=o.77, pcholesterol were highly significant /r=o.51, pcholesterol concentration. 3. N-acetyl-β-gluoosaminidase. a lysosomal hydrolase was found to be increased in diabetic children and directly related to the percentage of HbA1 fasting blood glucose and HDL-cholesterol. The present examinations extend the influence of juvenile diabetes on HDL-cholesterol concentration by the observation that the poorer the metabolic control the higher the HDL-cholesterol content in the plasma.