The allergen-specific immunotherapy efficiency in dependent on patient's parasitic status

Aim of this study is to evaluate the effectiveness of allergen-specific immunotherapy (ASIT) for allergic children depending on diagnosis of the Ascariasis, Toxocaros, Giardiasis. Materials. Group I of non-infested patients includes 55 children, aged 12.4±2.4. Group II of patients with combined behaviour of allergic pathology and invasion includes 18 children, aged 11.8±1.2. Frequency of atopic dermatitis in the groups was 91% and 67%, all children had allergic rhinitis; half of the children had bronchial asthma. Eosinophilia was noted in 33% and 17%. Total serum IgE level was 325±205 and 655±46 IU/ml. All children received ASIT with allergens depending on sensibilization detected. Effectiveness of ASIT courses was estimated in points from 0 to 4. Results. Evaluation of ASIT courses shows that this therapy was more or less effective in all cases. Yet in Group I low ASIT effect (2 points) was detected thrice less frequently than in infested children from Group II (10.9±4.3% as compared to 33,3±7.5%). Maximum effectiveness of ASIT was statistically more frequently detected in non-infested patients: in 49.1±6.8% of Group I, as compared to 16.7±7.5% (p Conclusion. Lower effectiveness of ASIT in infested patients is explained by the fact that parasitical agents actively interferes in patient9s immune system. We suggest that in order to increase the effectiveness of ASIT all children with allergic pathologies should receive high-quality parasitical examination and consequent antiparasitical therapy in case of a detected invasion.