Total synthesis of (+/-)-neovibsanin B.

Hiroshi Imagawa,Hayato Saijo,Takahiro Kurisaki,Hirofumi Yamamoto,Miwa Kubo,Yoshiyasu Fukuyama,Mugio Nishizawa

Total synthesis of (+/-)-neovibsanin B.

2009

Hiroshi Imagawa
Hayato Saijo
Takahiro Kurisaki
Hirofumi Yamamoto
Miwa Kubo
Yoshiyasu Fukuyama
Mugio Nishizawa

(±)-Neovibsanin B was synthesized based on a DMI-accelerated intramolecular Diels−Alder reaction followed by oxy-Michael addition−lactonization. The synthetic (±)-neovibsanin B induced similar morphological changes in NGF-mediated PC12 cells compared with natural (+)-neovibsanin B.

Keywords:

Stereochemistry
Total synthesis
Neovibsanin B
Organic chemistry
Chemistry
Intramolecular force

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