Synthesis of Polysubstituted Pyrroles via Pd-Catalyzed Oxidative Alkene C–H Bond Arylation and Amination

A novel Pd(II)-catalyzed oxidative approach to construct polysubstituted pyrroles from N-homoallylicamines and arylboronic acids was developed. This transformation is supposed to proceed through cascade formation of C–C and C–N bonds via oxidative arylation of unactive alkenes, followed by intramolecular aza-Wacker cyclization.