Tröger’s bases in the acronycine, benzo[a]acronycine, and benzo[b]acronycine series
2011
Abstract Reaction of 11-aminoacronycine, 10-aminobenzo[ a ]acronycine, and 10-aminobenzo[ b ]acronycine with paraformaldehyde gave the corresponding Troger’s bases 11 , 14 , and 16 , respectively. The cytotoxic activity of those three new compounds was determined against L-1210 leukemia and KB-3-1 solid tumor cell lines, in comparison with their parent compounds, acronycine, benzo[ a ]acronycine, and benzo[ b ]acronycine.
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