Recent progress in fluorescent probes for detection of carbonyl species: Formaldehyde, carbon monoxide and phosgene

Abstract Extensive attention has been paid to develop effective systems for the detection of formaldehyde, carbon monoxide and phosgene due to their extreme toxicity and ready accessibility. Numerous methods have been developed for the design and detection of these substances nowadays, such as electro-fluorescent biosensors, piezoelectric sensors, semiconductor sensors, colorimetric probes, quartz crystal microbalance, Raman spectroscopy, transmission electro-microscopy (TEM), gas chromatography, liquid chromatography and X-ray diffraction (XRD), but fluorescent probes, which rely on chemical reactions between the probes and the target, provoking a dramatic fluorescence change, often remain the most commonly employed method for detecting such important small molecules. This review will cover the most significant developments in fluorescent probes for the detection of the carbonyl species formaldehyde, carbon monoxide and phosgene in recent years (typically the last 10 years), with a special emphasis on their mechanisms and applications.