Styrylpyrone Derivatives From Goniothalamus dolichocarpus

Styrylpyrone derivatives (+)-goniothalamin (1), (+)-goniothalamin epoxide (2) and (–)-iso-5-deoxygoniopypyrone (4b), and the acetogenin (+)-annonacin (7) were bioactive compounds isolated from the stem bark of Goniothalamus dolichocarpus. The stereochemical relationships for (+)-goniothalamin epoxide (2), (+)-isogoniothalamin epoxide (3) and (+)-goniodiol diacetate (6) were established by chemical transformations and single-crystal X-ray crystallography.