Citrafungins A and B, Two New Fungal Metabolite Inhibitors of GGTase I with Antifungal Activity

Screening of natural products extracts led to the discovery of citrafungins A and B, two new fungal metabolites of the alkylcitrate family that are inhibitors of GGTase I of various pathogenic fungal species with IC50 values of 2.5−15 μM. These compounds exhibited antifungal activities with MIC values of 0.40−55 μM. The isolation, structure elucidation, relative and absolute stereochemistry, and biological activities of citrafungins are described.