Activity of peptide hydrolases and trypsin inhibitor in psoriasis

Distinct activation of alkaline and trypsinlike proteinases, leucine aminopeptidase as well as inhibition of the antitryptic activity (ATA) occurred in the area of impaired skin and in peripheral blood of patients with psoriasis as shown by clinico-laboratory examinations. These data suggest the epidermal origin of the substance inhibiting the enzymatic activity. After administration into animals of homogenates of impaired skin obtained from the patients an increase in BAEE-esterase activity and a decrease in the ATA were observed in blood serum. A reverse correlation was found between the ATA of parakeratotic layer and amount of eosinophils in peripheric blood.