Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.

Autoreactive B cell-derived antibodies form immune-complexes that likely play a pathogenic role in autoimmune diseases. In Systemic Lupus Erythematosus (SLE), these antibodies bind Fc receptors on ...