Age related clinical presentation and laboratory parameters in juvenile SLE: a Hungarian multicenter study.

Results Female:Male ratio was 9:1 in both groups. The most common initial manifestations as butterfly rash occured in 60%/62%, cytopenias 60%/57%, kidney involvement 47%/43%, serositis 27%/23%, in the pre/postpubertal group. Arthritis was significantly more common in the older group (57%/77%). General symptomes like fever 47%/57%, weight loss 23%/30%, increased infection rate 20%/13% were also similar in the two age groups, as did ANA, anti-dsDNA, anti-Sm, anti-SSA, anti-SSB positivity and low C3 and C4 levels. Anti-RNP antibody was more common in the younger ages (33%/10%). Mean SLEDAI score was 12 in both groups. Zero SLICC damage index is significantly more common (68%/43%) in the older group after comparable follow-up period.