TINNITS DUE TO STREPTOMYCIN INTOXICATION

On 90 patients with hearing disturbance due to streptomycin administration, the clinical character of the tinnitus was observed. Tinnitus would occur in the early stage of cochlear involvement by streptomycin intoxication and could occur even following to a single injecton of 1 gram streptomycin. On acute cases, tinnitus would occur within several hours after the streptomycin injection and disappear in several hours spontaneously. No change was observed on a threshold audiogram in about 30 % of the ears with the tinnitus. In most of the cases, tinnitus appeared prior to the development of deafness, therefore tinnitus was regarded as one of the most important prodromal symptoms of streptomycin intoxication.