Молекулярные механизмы нарушений импринтированных генов при патологии эмбрионального развития и привычном невынашивании беременности

It was found that disturbances of embryonic development are accompanied by multi-locus imprinting disturbance (MLID), the frequency of which is increased in placental tissues of spontaneous abortions from women with recurrent pregnancy loss. It is shown that MLID are accompanied by NLRP7 gene mutations in spontaneous abortions from women with recurrent pregnancy loss, and parents are heterozygous carriers of these mutations.