A Clinical Study of Plasma Lysophospholipids Levels in Patients with Intracerebral Hemorrhage and Effects of Mini-invasive Evacuation of Hematoma

Objective To investigate the changes of plasma lysophosphatidic acid (LPA) and acidic phospholipid (AP) levels in patients with intracerebral hemorrhage (ICH) and to evaluate whether the treatment with mini-invasive evacuation of hematoma combined with magnesium sulfate will decrease the AP level and affect patients’ outcome. Methods We examined plasma LPA and AP levels using fresh fetched blood in 328 cases of ICH, 310 controls and 359 cases of ischemic stroke enrolled in our study. Meanwhile, the effects of mini-invasive evacuation of hematoma combined with magnesium sulfate on plasma LPA/AP levels and patients’ prognosis were observed. Results Within 24 hours after onset, a signifi cantly elevated LPA level was seen in cases (n=359) with ischemic stroke [(4.23±0.61)μmol/L], compared with control group[(2.54±0.39)μmol/L, (P0.01)] and ICH group[(2.66±0.44)μmol/L, (P0.01)]. AP level significantly increased in ICH group [(6.65±0.76)U], when compared with the control group [(4.09±0.48)μmol/L, P0.01] and ischemic stroke group[(5.35±0.57)U, P0.01]. The high level of AP in ICH group lasted 2 weeks. Mini-invasive evacuation of hematoma combined with intravenous magnesium sulfate signifi cantly lowered the patients’ AP level compared with administration of medicine expectant treatment(P0.01), and functional assessment of neurologic system was obviously improved (P0.01). Conclusion The plasma AP level increases in acute stage of ICH, which suggests a close association between ICH and ischemic membrane injury. Mini-invasive evacuation of hematoma combined with magnesium sulfate can effectively reduce the plasma AP level and improve patients’ prognosis.