Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity
2016
Clec4A4 is a C-type lectin receptor highly expressed by CD8α− dendritic cells. Here the authors show that its loss of function results in enhanced T cell responses and exacerbated autoimmunity, implicating Clec4A4 in limiting activation of the CD8α− dendritic cells.
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