Sustained HIV RNA suppression after switching from enfuvirtide to etravirine in the early access programme

adults and one child). Oral valaciclovir was well tolerated in our very young children and can be considered for long-term treatment such as in relapsing HSV encephalitis or disease with focal destruction lesions on neuroimaging where prolonged iv aciclovir therapy is not practical and oral aciclovir has poorer bioavailability. Provided aciclovir concentrations are monitored and the administration of valaciclovir tolerated, the valaciclovir dose can be titrated upwards either to achieve plasma concentrations equivalent to those reported after a particular iv aciclovir administration dose or to a theoretically calculated target dose, as in our cohort.