C型肝炎ウイルス (HCV) 抗体スクリーニングによる輸血後肝炎の減少

We examined the effect of donor blood screening of HCV antibody on the reduction of the incidence of posttransfusion hepatitis (PTH).Before this screening period, from September 1 to November 13, 1989, 263 cases in Hokkaido area were given with the mean dose of 11.0 units and followed for more than 3 months. Fourteen cases were diagnosed as posttransfusion hepatitis (5.3%), i. e. 9 cases definite, and 5 cases probable. Eight patients were diagnosed as hepatitis C, since either sera from patients themselves or donor blood samples turned out to be positive for aniti-HCV retrospectively.After the screening period, from November 14, 1989 to July 31, 1990, 555 cases were given with the mean dose of 14.2 units and followed for more than 3 months. Twelve cases were diagnosed as PTH (2.2%), i. e. 5 cases definite, and 7 cases probable. In 5 cases patient's anti-HCV converted to positive and in one of those cases two of the implicated donors seroconverted after the blood donation.In conclusion, it was revealed that incidence of PTH reduced from 5.3% (14/263) to 2.2% (12/555) significantly by HCV antibody screening of donor blood.