Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain

AbstractThe latent sensitization model of chronic pain reveals that recovery from some types of long-term hyperalgesia is an altered state in which nociceptive sensitization persists but is suppressed by the ongoing activity of analgesic receptors such as μ-opioid receptors (MORs). To determine whet