Langerhans cell histiocytosis in adults:a clinicopathologic analysis of 5 cases

Objective To investigate the clinicopathologic features,immunophenotype and prognosis of Langerhans cell histiocytosis(LCH) in adults.Methods Analysis of 5 cases of clinical and pathological features of adult LCH,while the SP immunohistochemical staining were performed for LCH immune phenotype.The encoded small RNA was detected by in situ hybridization.Results The 5 adult patients with LCH were male,aged 21-29 years old.Histological changes included: diffused distribution of Langerhans cells,the cells medium to relatively large,lightly stained to eosinophilic cytoplasm,nuclear were round,oval,bean-like or irregular in shape,showing nuclear grooves and depressions,inter-rich quality of the small blood vessels and fibroblasts,and the different number of eosinophils,lymphocytes and neutrophil infiltration.Langerhans cells expressed S-100,CD68 and CD1a,expressed varying degrees of P53,and Ki-67 proliferation index showed 5%~15%.In situ hybridization showed: The cases were negative for EBER.Conclusions Adults LCH can occur in cranio-orbital cavity,auditory canal,perianal and back skin.The prognosis is better when surgical resection is combined with other treatments.