Electrical stimulation devices of a biological tissue and its calibration method.

electrical stimulation system (SSE) comprising: - means (BMI) for generating at least one electrical signal to be applied to a biological tissue to be stimulated (TB) and for measuring a response of said biological tissue to said or each said electrical signal; - calculation means (MC1, MC2) for estimating, from the knowledge of said or each said electrical signal and the corresponding response of said biological tissue, at least one parameter of an electrical model of said biological tissue and its interface with said electrical stimulation system and to determine, using said model, at least one parameter of a stimulation pulse to be applied to said biological tissue by means of said electrical stimulation system; and - means (BGS) for generating a said pacing pulse to be applied to said biological tissue. integrated circuit for controlling such an electrical stimulation system. A method of calibrating such an electrical stimulation system.