Effects of Bao-gan-kang-lao Decoction on Experimental Acute Hepatic Injury
2010
Objective: To observe the protective effect of Bao-gan-kang-lao decoction on acute hepatic injury.Methods: The acute hepatic injury model of mice was induced by carbon tetrachloride and anti-tuberculosis drugs Rifampacin and Isoniazid.We measured the changes of serum ALT,AST and liver index after the administration of the Bao-gan-kang-lao decoction for 6 days,and observed the acute toxicity of Bao-gan-kang-lao decoction.Results: Bao-gan-kang-lao decoction with the dose of 22 and 44 g·kg-1·d-1 could obviously reduce the levels of ALT and AST and the coefficient of liver weight induced by carbon tetrachloride and anti-tuberculosis drugs Rifampacin and Isoniazid.The maximum dosage to mice was 225 g·kg-1·d-1 155 times of human clinical dosage.Conclusions: Bao-gan-kang-lao decoction has protective effect on liver injury induced by carbon tetrachloride and anti-tuberculosis drugs Rifampacin and Isoniazid.Bao-gan-kang-lao decoction has not much toxicity,and is safe and reliable in clinic.
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