Chronic thrombo-embolic pulmonary hypertension: Long-term outcomes in operated and non-operated patients

Introduction: Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a life shortening condition that may be cured by pulmonary endarterectomy.However, patients may not undergo surgery due to disease distribution, comorbidities or patient choice. Aims and objectives: To compare long term survival of patients with CTEPH undergoing pulmonary endarterectomy (CTEPH-surgical-operated), surgically accessible disease not undergoing endarterectomy due to comorbidities/patient choice (CTEPH-surgical-not-operated) and surgically inaccessible disease (CTEPH-non-surgical). Methods: Data was retrieved from the Sheffield ASPIRE Registry for consecutive, treatment-naive patients with CTEPH diagnosed between 2001 and 2015. Results: 613 patients, mean age(±standard deviation), 62±15 years, mean pulmonary arterial pressure 46±11mmHg and pulmonary vascular resistance 622±348dynes were identified and followed for 4.5±3.5 years. 5 year survival was significantly (p Conclusions: For patients with operable CTEPH pulmonary endarterectomy is associated with an excellent long term survival as previously reported. In addition we have shown that long-term survival of patients with surgical disease who decline surgery is significantly better than previously reported.