Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA
1990
Abstract Human papilloma virus (HPV) DNA sequences (HPV types 16,18, 33, 35 or uncharacterised) were detected by Southern blot hybridisation and polymerase chain reaction in 84% of 106 early-stage invasive carcinomas of the uterine cervix. Among HPV-positive patients, the risk of overall relapse did not differ with individual HPV types. Compared with HPV-positive patients, those with no detectable HPV DNA had a 2·6 times higher risk of overall relapse (p
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