Effect of acetoacetate on liver and blood pyridine nucleotides in rats.

Experiments were carried out to study the effect of acetoacetate admini-stration on pyridine nucleotides in liver and blood in male albino rats. Acetoacetate, when administered along with tryptophan (through diet) to tryptophan-niacin-deficient rats for twenty days, resulted in decreased pyridine nucleotide values as compared to the corresponding controls. Prolonged administration of acetoacetate to rats kept on normal diet decreased the pyridine nucleotide contents of liver and blood.