Old Web
crude bran extracts and fractions of selected traditional red rice oryza sativa l varieties of sri lanka potentiates anti inflammatory activities in human blood and cell assays
2018
1. Abstract Crude extracts (70% ethanolic)
and fractions (hexane, dichloromethane, butanol, aqueous ) of brans of four Sri Lankan
traditional red rice varieties ( Oryza
sativa L. ) , namely, Sudu Heeneti, Goda Heeneti, Masuran
and Dik Wee were studied for a range of anti-inflammatory activities. The
investigated activities included oxidative burst inhibitory activity in human
whole blood, isolated human polymorphonuclear cells and mice peritoneal
macrophages and inhibition of nitric oxide and pro-inflammatory cytokines in cell assays. Further, cytotoxicity was
evaluated against
normal cell line . The results showed for the first time that brans
of all the rice varieties selected for the current study had anti-inflammatory
activities in all the assays tested without inducing cytotoxicity on normal
cells. However, significant differences were observed among different varieties
and between crude extracts and fractions for investigated anti-inflammatory
activities. Partitioning of crude rice bran extracts
showed inhibitory activities in both non-polar and polar fractions. The non-pigmented
dichloromethane fractions exhibited anti-inflammatory activities in all the assays studied. Overall, the properties
observed indicate usefulness of brans of selected Sri Lankan traditional red
rices in the management of inflammation associated chronic diseases.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI