The association between sterilizing activity and drug distribution into tuberculosis lesions.

Brendan Prideaux,Laura E. Via,Matthew Zimmerman,Seok-Yong Eum,Jansy Sarathy,Paul O'Brien,Chao Chen,Firat Kaya,Danielle M. Weiner,Pei-Yu Chen,Taeksun Song,M. Lee,Tae Sun Shim,Jeong Su Cho,Wooshik Kim,Sang-Nae Cho,Kenneth N. Olivier,Clifton E. Barry,Véronique Dartois

The association between sterilizing activity and drug distribution into tuberculosis lesions.

2015

Brendan Prideaux
Laura E. Via
Matthew Zimmerman
Seok-Yong Eum
Jansy Sarathy
Paul O'Brien
Chao Chen
Firat Kaya
Danielle M. Weiner
Pei-Yu Chen
Taeksun Song
M. Lee
Tae Sun Shim
Jeong Su Cho
Wooshik Kim
Sang-Nae Cho
Kenneth N. Olivier
Clifton E. Barry
Véronique Dartois

MALDI mass spectrometry shows distinct patterns of drug distribution in tuberculosis lesions in human lungs that provide insight into treatment efficacy.

Keywords:

Pharmacodynamics
Immunology
Mycobacterium tuberculosis
Antibiotics
Pyrazinamide
Medicine
Tuberculosis
Pathology
Drug resistance
Lesion
Drug development
Rifampicin

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