5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

Abstract A series of 5-phenyl-substituted- N -alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation.